Hugh Laurie, wildly popular in the U.S. for his lead role in the Fox network series House, stars as Paul Slippery, an anxiety-ridden British doctor suffering from a mid-life crisis. He can't remember exactly where his wife works, or whether she works at all. He's concerned that perhaps his children may have a more active love life than he has and he's begun to hear the unspoken thoughts inside other people's heads. Slippery's wife, Estelle (Anna Chancellor, Four Weddings and a Funeral), has embarked on a new career and perhaps an extramarital affair or two. His three adolescent sons mock him without mercy, and at work he's tangled in red tape and tormented by a flaky colleague. Guest stars include Stephen Fry, Laurie's partner-in-comedy from shows such as A Bit of Fry and Laurie, Jeeves and Wooster, and Blackadder. Hugh Laurie also directed the series. With its delightful cast and zany repartee, Fortysomething turns the fears and foibles of middle age into surreal high comedy of the kookiest kind.